2017-8-11 16:0:3Mon May 16 2016 16:20:52 GMT+0200 (CEST)
proteinLength
518
geneLength
1554
Gene
Coordinates
2,892,138 → 2,893,694
The protein
Catalyzed reaction/ biological activity
Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA (according to Swiss-Prot)
Acetyl-CoA
The protein
Additional information
subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
:
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
[SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins], [SW|most abundant proteins]
Gene
Coordinates on the chromosome (coding sequence)
2,892,138 -> 2,893,694
Expression and Regulation
Operon
''[[protein|ilvB]]-[[protein|ilvH]]-[[protein|ilvC]]-[[protein|leuA]]-[[protein|leuB]]-[[protein|leuC]]-[[protein|leuD]]'' [Pubmed|1577690]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|1577690]
Expression and Regulation
Regulation
for a complete overview on the regulation of the ilv operon, see [http://www.ncbi.nlm.nih.gov/pubmed/20935095 Brinsmade ''et al''.]
repressed by casamino acids [Pubmed|12107147]
expression is stimulated in the presence of glucose [Pubmed|12193635]
repressed in the absence of good nitrogen sources (glutamine or ammonium) ([[protein|TnrA]]) [Pubmed|15547269]
repressed during growth in the presence of branched chain amino acids ([[protein|CodY]], [[protein|T-box]]) [Pubmed|12618455]
Expression and Regulation
Regulatory mechanism
[[protein|CodY]]: transcription repression [Pubmed|12618455]
[[protein|CcpA]]: transcription activation [Pubmed|12193635]
[[protein|T-box]]: tRNA-controlled [SW|RNA switch] that mediates termination/antitermination
[[protein|TnrA]]: transcription repression [Pubmed|15547269]
Expression and Regulation
Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=
An [[ncRNA|antisense RNA]] is predicted for'[[protein|leuA]]' [PubMed|20525796]
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]